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10 mai 2010

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Combined, the effects of STC1 on endothelial cells and macrophages predict potent christian louboutin anti-inflammatory action. Indeed, application of the anti-glomerular basement membrane (GBM) glomerulonephritis model to STC1 transgenic mice that display increased expression of STC1 transgene in endothelial cells and macrophages yields renal protection. Our data suggest that STC1 activates antioxidant pathways in endothelial cells and macrophages and displays Christian Louboutin Sandals cytoprotective and anti-inflammatory actions. [PUBLICATION ABSTRACT]Epithelial sodium channels (ENaC) are regulated by protein kinase A, in addition to a broad spectrum of other protein kinases. It is not clear whether cGMP/PKG signaling might regulate ENaC activity. We examined the responses of -ENaC channels expressed in Xenopus oocytes louboutin sale to 8-(4-chlorophenylthio)-cGMP (8-pCPT-cGMP), a cell-permeable cGMP analog. This compound stimulated human .-ENaC activity in a dose-dependent fashion, but cell-impermeable cGMP had no effect. Similar stimulatory effects of cGMP were observed in oocytes expressing either mouse or rat -ENaC channels. The identical ion selectivity Christian Louboutin Pumps sale and amiloride sensitivity of the 8-pCPT-cGMP-activated currents to those of 伪尾...-ENaC channels suggest that the cGMP-activated currents are associated with expressed ENaC.

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